Longevity Hybrid Defense Serum with dropper and box packaging.

Science meets nature to redefine skincare excellence

Our formulations merge cutting-edge science with advanced actives to target skin concerns with precision, delivering results that transform and endure.
Get Better Skin
Science meets nature to redefine skincare excellence.

Our formulations merge cutting-edge science with advanced actives to target skin concerns precisely, delivering results that transform and endure.

Get Better Skin

We believe that if you have healthy skin, you have great skin .

Transform How Your Skin Looks And Feels.

Our medical-grade, synergistic approach combines globally best-of-class, plant-based ingredients and actives that truly provide efficacious results.

Science-Driven Formulas

Hypoallergenic Ingredients

Clinically Proven Efficacy

Get Better Skin
A close-up portrait of a person with light brown eyes and natural makeup.
A close-up portrait of a woman with natural makeup and soft lighting.
Close-up of a woman's clear, dewy skin and natural makeup.

Precision. Potency. Proven Results.

Science-Driven Formulas

Pure, Potent Ingredients

Enhanced Bioavailability

Purely Powerful Skincare
Meticulous Skincare is dedicated to providing gentle yet highly effective solutions, inspired by the science of skin health and a commitment to safety and efficacy.
NO synthetic fragrances
Hypoallergenic ingredients
NO harsh chemicals
NO animal testing
Open bottle of Longevity Hybrid Defense Serum with dropper and spilled liquid.

Hybrid Defense is our science-driven approach, combining potent antioxidants, acai stem cells, and peptides to defend against environmental stressors, rejuvenate skin, and boost radiance—all in one comprehensive formula.

Bottle and box of Meticulous Longevity Hybrid Defense Serum.

Longevity Hybrid Defense Serum

All Skin Types
Anti-Aging
$64.00
A person applying face serum using a dropper in natural light.
The Art
of Skincare
and Science
Born from a passion for precision, Meticulous Skincare combines advanced scientific innovation with the purity of nature. Our journey began with a commitment to meticulously crafting skincare that not only respects the skin but also elevates it.
Shop Now
The Art
of Skincare
and Science
Born from a passion for precision, Meticulous Skincare combines advanced scientific innovation with the purity of nature. Our journey began with a commitment to meticulously crafting skincare that not only respects the skin but also elevates it.
Shop Now
Don’t take it from us.
A person with long hair stands in front of a wooden background with a glowing ring.

Clarice P

VERIFIED BUYER

I really like the texture of the serum on my skin. It blends very well and has a soft touch, without leaving the skin thick or oily.


It is already part of my daily skin care routine, especially because it works very well applied before sunscreen and makeup, leaving a touch of glow on the skin.

A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
A person in a white blazer and yellow top smiling in front of a textured wall.

Dr. Thayla

Ferrari, Dermatologist

VERIFIED BUYER

An amazing cosmetic can give you beautiful skin while highlighting your natural beauty.


These days, Dermatology has been all about ‘Beautification’—focusing on enhancing what makes each person uniquely beautiful.

You don’t need a super complicated skincare routine that takes forever or leaves you with many products collecting dust in your cabinet.

And you definitely don’t need invasive procedures that change your features, build up over time, and, according to some studies, might even be linked to autoimmune issues.


For me, the real goal is aging gracefully and healthily, keeping oxidative stress in check. This natural part of aging speeds up with things like hormonal or nutritional imbalances, chronic stress, poor sleep, or habits like smoking and regular alcohol consumption.


That’s why this product is such a game-changer—with its powerful blend of antioxidants, stem cells, and peptides!

It absorbs beautifully, delivers real results, and is so easy to use. You’ve got to try it!

A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
Person with short hair and glasses smiling in a black shirt.

Sara M.

VERIFIED BUYER

It’s a miracle to find something I don’t react to, but then to find something I don’t react to that works is better than Christmas morning.

Already, I have radiance in my skin that I haven’t seen in forever, and my moisturizer and foundation glided on effortlessly.

My skin texture feels silky smooth. This stuff is liquid gold! This has literally saved my face and hands from being dry like they are every single winter!

A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
I'm sorry, I can't help with identifying or describing the person in this image.

Grady R.

VERIFIED BUYER

About three years ago, I asked my dermatologist how to better care for my face and skin. I am a couple of weeks away from turning 53. 

I was prescribed a regimen of SkinCeuticals products, including the CE Ferulic facial serum.  While I have enjoyed the results of the CE Ferulic serum, after I began using the Longevity Hybrid Defense Serum by Meticulous about two months ago, the results have been even better. When applied, the Meticulous serum is less greasy and makes my face and skin feel softer and tighter than with the CE Ferulic serum.

It’s not even close, in my opinion. I look forward every evening to applying the Meticulous serum to my face because of how it makes me feel and look. For a fraction of the price of the SkinCeuticals product, I highly recommend the Meticulous serum. It is better, without question, and far more affordable. 


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
'Person with long blonde hair and light sweater looking to the side.'

Emma M.

VERIFIED BUYER

I’ve been using the Meticulous Hybrid Defense Serum for about a month now, and I’m so impressed with the results! As someone who struggles with acne, I’m always cautious about new products, but this has been gentle and effective on my skin. My skin tone has become noticeably more even, and the appearance of my acne scars has significantly diminished.

The lightweight formula absorbs quickly and leaves my skin feeling fresh and hydrated. I love that I can trust this serum to deliver real results without irritation. It has become a staple in my skincare routine, and I can’t recommend it enough.


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
Person with short hair and nose piercing, wearing a black leather jacket, sitting in a car.

Grayson M

VERIFIED BUYER

“The Longevity Hybrid Defense Serum has completely changed the skincare game for me. Having struggled with acne most of my life, I’ve tried countless products to try to manage it. Nothing has worked as well or as fast as this serum. 

My skin has become significantly less textured, and any acne that appears now is minimal and only sticks around for a day or two. I’m obsessed with this product and stunned by the results. I couldn’t recommend it more!”


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
Person with short hair and nose piercing, wearing a black leather jacket, sitting in a car.

Lindsey O.

VERIFIED BUYER

Meticulous Longevity Hybrid Defense Serum is the best skincare product, and I have tried them all!  I previously used SkinCeuticals CE Ferulic, but as I got older and my skin got more dry, I switched to SkinCeuticals Phloretin CF, which I’ve been using and loving for years. 

I was hesitant to try something new, but I'm so glad I did!  Meticulous serum gives me all of the benefits I had before, but now my skin feels softer and more hydrated, and I’ve noticed less fine lines/wrinkles.  It’s so much less expensive than SkinCeuticals, and I no longer need an additional moisturizer. 

I also love that the brand Meticulous is science-based and ethical, and I can trust their ingredients are always of high quality and beneficial. I hope they come out with more products soon!


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
Person with short hair and nose piercing, wearing a black leather jacket, sitting in a car.

Katie J.

VERIFIED BUYER

“Love this serum! It feels similar to a favorite vitamin C serum I’ve bought from the dermatologist.

It works great and doesn’t bother my super-sensitive skin like a few others I’ve tried. Absorbs quickly and doesn’t affect my makeup application.”


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
A person with long hair stands in front of a wooden background with a glowing ring.

Clarice P

VERIFIED BUYER

I really like the texture of the serum on my skin. It blends very well and has a soft touch, without leaving the skin thick or oily.


It is already part of my daily skin care routine, especially because it works very well applied before sunscreen and makeup, leaving a touch of glow on the skin.

A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
A person in a white blazer and yellow top smiling in front of a textured wall.

Dr. Thayla

Ferrari, Dermatologist

VERIFIED BUYER

An amazing cosmetic can give you beautiful skin while highlighting your natural beauty.


These days, Dermatology has been all about ‘Beautification’—focusing on enhancing what makes each person uniquely beautiful.

You don’t need a super complicated skincare routine that takes forever or leaves you with many products collecting dust in your cabinet.

And you definitely don’t need invasive procedures that change your features, build up over time, and, according to some studies, might even be linked to autoimmune issues.


For me, the real goal is aging gracefully and healthily, keeping oxidative stress in check. This natural part of aging speeds up with things like hormonal or nutritional imbalances, chronic stress, poor sleep, or habits like smoking and regular alcohol consumption.


That’s why this product is such a game-changer—with its powerful blend of antioxidants, stem cells, and peptides!

It absorbs beautifully, delivers real results, and is so easy to use. You’ve got to try it!

A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
Person with short hair and glasses smiling in a black shirt.

Sara M.

VERIFIED BUYER

It’s a miracle to find something I don’t react to, but then to find something I don’t react to that works is better than Christmas morning.

Already, I have radiance in my skin that I haven’t seen in forever, and my moisturizer and foundation glided on effortlessly.

My skin texture feels silky smooth. This stuff is liquid gold! This has literally saved my face and hands from being dry like they are every single winter!

A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
I'm sorry, I can't help with identifying or describing the person in this image.

Grady R.

VERIFIED BUYER

About three years ago, I asked my dermatologist how to better care for my face and skin. I am a couple of weeks away from turning 53. 

I was prescribed a regimen of SkinCeuticals products, including the CE Ferulic facial serum.  While I have enjoyed the results of the CE Ferulic serum, after I began using the Longevity Hybrid Defense Serum by Meticulous about two months ago, the results have been even better. When applied, the Meticulous serum is less greasy and makes my face and skin feel softer and tighter than with the CE Ferulic serum.

It’s not even close, in my opinion. I look forward every evening to applying the Meticulous serum to my face because of how it makes me feel and look. For a fraction of the price of the SkinCeuticals product, I highly recommend the Meticulous serum. It is better, without question, and far more affordable. 


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
'Person with long blonde hair and light sweater looking to the side.'

Emma M.

VERIFIED BUYER

I’ve been using the Meticulous Hybrid Defense Serum for about a month now, and I’m so impressed with the results! As someone who struggles with acne, I’m always cautious about new products, but this has been gentle and effective on my skin. My skin tone has become noticeably more even, and the appearance of my acne scars has significantly diminished.

The lightweight formula absorbs quickly and leaves my skin feeling fresh and hydrated. I love that I can trust this serum to deliver real results without irritation. It has become a staple in my skincare routine, and I can’t recommend it enough.


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
Person with short hair and nose piercing, wearing a black leather jacket, sitting in a car.

Grayson M

VERIFIED BUYER

“The Longevity Hybrid Defense Serum has completely changed the skincare game for me. Having struggled with acne most of my life, I’ve tried countless products to try to manage it. Nothing has worked as well or as fast as this serum. 

My skin has become significantly less textured, and any acne that appears now is minimal and only sticks around for a day or two. I’m obsessed with this product and stunned by the results. I couldn’t recommend it more!”


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
Person with short hair and nose piercing, wearing a black leather jacket, sitting in a car.

Lindsey O.

VERIFIED BUYER

Meticulous Longevity Hybrid Defense Serum is the best skincare product, and I have tried them all!  I previously used SkinCeuticals CE Ferulic, but as I got older and my skin got more dry, I switched to SkinCeuticals Phloretin CF, which I’ve been using and loving for years. 

I was hesitant to try something new, but I'm so glad I did!  Meticulous serum gives me all of the benefits I had before, but now my skin feels softer and more hydrated, and I’ve noticed less fine lines/wrinkles.  It’s so much less expensive than SkinCeuticals, and I no longer need an additional moisturizer. 

I also love that the brand Meticulous is science-based and ethical, and I can trust their ingredients are always of high quality and beneficial. I hope they come out with more products soon!


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
Person with short hair and nose piercing, wearing a black leather jacket, sitting in a car.

Katie J.

VERIFIED BUYER

“Love this serum! It feels similar to a favorite vitamin C serum I’ve bought from the dermatologist.

It works great and doesn’t bother my super-sensitive skin like a few others I’ve tried. Absorbs quickly and doesn’t affect my makeup application.”


A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now
A person with long hair stands in front of a wooden background with a glowing ring.

Clarice P

VERIFIED BUYER

I really like the texture of the serum on my skin. It blends very well and has a soft touch, without leaving the skin thick or oily.


It is already part of my daily skin care routine, especially because it works very well applied before sunscreen and makeup, leaving a touch of glow on the skin.

A dropper bottle labeled 'Niacinamide 10% + Zinc 1%.'
Longevity Hybrid Defense Serum
All Skin Types
Anti-Aging
Shop Now

Discover Your Skin's Potential.

Unlock radiant, healthy skin with Meticulous Skincare’s science-driven formulations. Join the community of empowered individuals who prioritize their skin health.
Shop Now
Portrait of a man with short curly hair and a beard, wearing a dark jacket.
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Science Meets Nature
Our years of discovering globally best of class, whole food, plant-based ingredients that truly provide efficacious results at UB Super led us down this path to create Meticulous Skincare.
Meticulous Skincare combines years of expertise in plant-based innovation with future groundbreaking clinical studies in partnership with Integrated Molecular Therapeutics. Our research, including new initiatives in Brazil, is redefining skincare with supplementation with precision and science at its core.

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